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  • Causes of increased D-dimer - acute care testing

    Application of the test in this way allows rapid exclusion of VTE without the necessity for expensive, time-consuming imaging tests. The low specificity of a positive D-dimer for VTE is strikingly highlighted by a recently published retrospective clinical study focusing on the use of D-dimer testing in an emergency department setting.

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  • Widely Used Types and Clinical Applications of D

    2016-3-25 · In contrast with a negative D-dimer result, a positive D-dimer assay result is nonspecific and can be caused by many diseases. A large retrospective study of 1647 patients, evaluated at a large urban medical center, whose specimens yielded a positive D-dimer result showed infection as the most common cause, followed by VTE, syncope, heart failure, trauma, and cancer.

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  • D-Dimer - Health Encyclopedia - University of

    What is this test? This is a blood test to look for a substance called D-dimer. This test is used to rule out a blood clot. D-dimer is a protein fragment from the break down of a blood clot. Blood clots generally start to slowly break down after they are formed, and this process releases D-dimer into the blood. Why do I need this test?

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  • D-Dimer Test: MedlinePlus Medical Test

    2021-6-10 · A D-dimer test looks for D-dimer in blood. D-dimer is a protein fragment (small piece) that's made when a blood clot dissolves in your body. Blood clotting is an important process that prevents you from losing too much blood when you are injured. Normally, your body will dissolve the clot once your injury has healed.

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  • Review of D‐dimer testing: Good, Bad, and Ugly -

    2017-4-26 · A D-dimer result is unhelpful when the pretest probability of VTE is “likely” for three reasons: (i) the result is unlikely to be negative even if VTE is not present (ie many of the factors that increase the risk of VTE will also increase D-dimer levels, eg cancer, recent surgery); (ii) a positive result still requires confirmatory imaging; and (iii) there is uncertainty that D-dimer testing can safely exclude VTE in this …

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  • Never ignore extremely elevated D-dimer levels: they

    Methods: Retrospective cohort study of patients > 18 years with an extremely elevated (> 5000 μg/l; > 10x cut-off to exclude VTE) D-dimer test result. Electronic medical records were reviewed for diagnoses. Results: A total of 759 extremely elevated D-dimer results were identified. After exclusion of 120 duplicate cases, 53 patients undergoing cardiopulmonary resuscitation, and 5 cases without diagnostic …

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  • Diagnostic management of inpatients with a positive D ...

    2020-2-21 · making appropriate decisions for patients with positive D-dimer results and reduce unnecessary CTPA examinations. In the present study, we developed a clinical decision-making rule that is based on positive D-dimer results. We combined clinical variables that can be observed in inpati-ents in real-time, including symptoms, signs and findings on

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  • Serum D-dimer should not be used in the diagnosis of ...

    2020-9-22 · Patients undergoing major surgery such as TKR can have a raised serum D-dimer secondary to activation of the fibrinolytic process and hence can lead to false positives for D-dimer tests in patients postoperatively, thus reducing the specificity of this test . Tourniquet application is frequently used during TKR surgery, which can lead to reported complications such as increased VTE risk, skin …

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  • D-dimer test, normal D-dimer level and elevated D

    A positive test means the D-dimer level in your body is higher than normal and suggests you might have blood clots. Blood clots form whenever a blood vessel is damaged, whether that’s by an injury or by atherosclerosis, or when blood flow is restricted, such as by a vessel being compressed for a long time.

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  • D-dimer: An Overview of Hemostasis and Fibrinolysis ...

    2015-1-1 · The finding of a D-dimer below the threshold published in the package insert can be used safely, but because of rising values, the test was below the threshold in patients without VTE in 50%, 22%, and 0% in patients in the first, second, and third trimesters, respectively; thus, there is an increased false positive value of the test, a problem that increases with the progression of the pregnancy along …

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  • Lab Test: D-dimer Level - EBM Consult

    D-dimer is a fibrin degradation fragment that is made through lysis of cross-linked (D-dimerized) fibrin. As plasmin acts on the fibrin polymer clot, fibrin degradation products and D-dimer are produced. The D-dimer assay provides a highly specific measurement of the amount of fibrin degradation that occurs.

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  • D-dimer: Simple Test, Tough Problems | Archives of ...

    2013-8-1 · Context.—D-dimer is widely used for exclusion, or as an aid in diagnosis, of venous thromboembolism (VTE); however, the D-dimer assay methods available from manufacturers and the laboratory application of those methods vary widely.. Objectives.—To describe the current laboratory practice regarding the assay and reporting of D-dimer.. Design.—Laboratories' D-dimer proficiency …

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  • D-dimer: An Overview of Hemostasis and Fibrinolysis ...

    2015-1-1 · The finding of a D-dimer below the threshold published in the package insert can be used safely, but because of rising values, the test was below the threshold in patients without VTE in 50%, 22%, and 0% in patients in the first, second, and third trimesters, respectively; thus, there is an increased false positive value of the test, a problem ...

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  • Serum D-dimer should not be used in the diagnosis of ...

    2020-9-22 · Serum D-dimer is frequently used to rule out a diagnosis of venous thromboembolism (VTE), a recognised complication following total knee replacement (TKR). TKR is known to cause a rise in D-dimer levels, reducing its specificity. Previous studies have demonstrated that D-dimer remains elevated within 10 days of TKR and therefore should be avoided.

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  • D-dimer test, normal D-dimer level and elevated D

    2020-9-22 · make the use of serum D-dimer an unacceptable screening test in the diagnosis of VTE in patients within 28days of TKR. With 96% of patient’shaving a positive D-dimer and only 4% (at 99days and 143 days post operatively) having a negative D-dimer, it would seem that in the vast majority of cases, the test

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  • Serum D-dimer should not be used in the diagnosis of ...

    2020-12-22 · The D-dimer test is said to have high sensitivity but low specificity. This example works because the disease (pulmonary embolism) has a trait (raised D-dimer) that is almost always present and the test looks for that trait. If the trait is not present, the disease is unlikely to be present. In the event of finding a positive test result ...

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  • Point-of-Care Testing for D-Dimer in the Diagnosis of ...

    Basically D-dimer is a fragment of fibrinogen formed by action of plasmin and its active presence helps to assist growth and progress of cancer towards metastasis and ultimately determine the prognosis of patient. Further studies on D-dimer levels; with authentic data and accuracy, can act as marker and help to fight against cancers ...

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  • D-Dimer Test: MedlinePlus Medical Test

    2021-6-10 · A D-dimer test is most often used to find out whether you have a blood clotting disorder. These disorders include: Deep vein thrombosis (DVT), a blood clot that's deep inside a vein. These clots usually affect the lower legs, but they can also happen in other parts of the body. Pulmonary embolism (PE), a blockage in an artery in the lungs.

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  • D-dimer: An Overview of Hemostasis and Fibrinolysis ...

    2015-1-1 · The finding of a D-dimer below the threshold published in the package insert can be used safely, but because of rising values, the test was below the threshold in patients without VTE in 50%, 22%, and 0% in patients in the first, second, and third trimesters, respectively; thus, there is an increased false positive value of the test, a problem ...

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  • Anti-D-dimer Antibodies | Invitrogen

    Antibodies that detect D-dimer can be used in several scientific applications, including ELISA, Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunocytochemistry. These antibodies target D-dimer in Mouse, Human and Canine samples. Our D-dimer monoclonal and polyclonal antibodies are developed in Mouse and Rabbit.

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  • D-dimer as an alarming biomarker in various cancers:

    Basically D-dimer is a fragment of fibrinogen formed by action of plasmin and its active presence helps to assist growth and progress of cancer towards metastasis and ultimately determine the prognosis of patient. Further studies on D-dimer levels; with authentic data and accuracy, can act as marker and help to fight against cancers ...

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  • Diagnosis of Venous Thromboembolism - Clinical

    2021-7-28 · D-dimer testing can be used to exclude recurrent PE in individuals with unlikely pretest probability. Use of an age-adjusted D-dimer cutoff in outpatients older than 50 …

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  • Tumor-Specific D-Dimer Concentration Ranges and ...

    2016-11-11 · D-dimer level in cancer patients is associated with risk of venous thromboembolism and deep venous thrombosis. Most cancer patients have “abnormal” D-dimer levels based on the current normal reference range. To investigate tumor-specific D-dimer reference range, we compared D-dimer levels for nine different tumour types with healthy controls by using simultaneous quantile regression …

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  • Do Normal D-dimer Levels Reliably Exclude Cerebral

    2004-10-28 · The D-dimer levels (mean±SD) were significantly higher in patients with CST than in patients in whom CST could be excluded (2052±1286, 375±368, respectively; P <0.0001). From the 35 neuroradiologically proven CST cases, there was only 1 (2.8%) who had a normal D-dimer …

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  • Effect of Exercise on D-Dimer Levels | Military

    2014-2-1 · A negative D-dimer can often exclude moderate-risk patients. We examined the change in D-dimer levels following strenuous exercise. Methods: In a prospective study of 42 sailors, D-dimer levels were drawn before and after a workout that simulated the standardized Navy Physical Readiness Test.

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  • D-dimer Normal Range - Health Hearty

    A false positive test result (in case of pregnancy, liver diseases, etc.) may show up, thus misleading someone regarding his D-dimer normal range. A false negative test, on the other hand, may be seen if the blood sample is taken too early after there is a thrombus formation, or if testing for the same has been delayed by many days.

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  • The DiPEP study: an observational study of the

    2018-5-21 · Sensitivities and specificities of D-dimer were 88.4% and 8.8% using a standard threshold and 69.8% and 32.8% using a pregnancy-specific threshold. Conclusions. Clinical decision rules and D-dimer should not be used to select pregnant or postpartum women …

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  • Anti-D-dimer Antibodies | Invitrogen

    Antibodies that detect D-dimer can be used in several scientific applications, including ELISA, Western Blot, Immunohistochemistry (Paraffin), Immunohistochemistry (Frozen) and Immunocytochemistry. These antibodies target D-dimer in Mouse, Human and Canine samples. Our D-dimer monoclonal and polyclonal antibodies are developed in Mouse and Rabbit.

    Get Price
  • Normal D-Dimer Levels in Patients With Pulmonary

    2014-2-1 · A negative D-dimer can often exclude moderate-risk patients. We examined the change in D-dimer levels following strenuous exercise. Methods: In a prospective study of 42 sailors, D-dimer levels were drawn before and after a workout that simulated the standardized Navy Physical Readiness Test.

    Get Price
  • Effect of Exercise on D-Dimer Levels | Military

    2019-4-26 · b) The clinical diagnosis of PE can be difficult. c) A D-dimer is a blood test used to rule out the presence of a blood clot. A negative or normal result means that it is most unlikely that a person has an abnormal clot. A positive result indicates that there may be a significant blood clot or thrombus but does not identify its location or cause.

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  • Record of Investigation into Death (Without Inquest)

    A false positive test result (in case of pregnancy, liver diseases, etc.) may show up, thus misleading someone regarding his D-dimer normal range. A false negative test, on the other hand, may be seen if the blood sample is taken too early after there is a thrombus formation, or if testing for the same has been delayed by many days.

    Get Price
  • D-dimer Normal Range - Health Hearty

    The test can reduce the number of imaging investigations in outpatients with a low pre-test likelihood for VTE. 7, 24– 27 However, if there is a high clinical suspicion of acute pulmonary embolism, diagnostic tests should proceed in spite of a normal D-dimer (in fact, D-dimer assay is useless in those with high clinical probability of ...

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  • Diagnosing pulmonary embolism | Postgraduate

    2013-5-3 · A negative D-dimer test can rule out venous thromboembolism in patients with a non-high clinical probability. Since D-dimer levels increase with age, the proportion of false positive D-dimer test results for venous thromboembolism using conventional cut-off values (500 µg/L) increases in older patients and the specificity decreases

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  • Diagnostic accuracy of conventional or age adjusted D ...

    Here is a scatter plot of the data. Each of the individual measurements for each sample are plotted. The x-axis is the expected concentration of D-dimer for each sample, and the y-axis is. the measured concentration. A linear regression line with a slope of 0.992 and intercept of - 0.001 was fit to the points.

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  • Calibration Verification and Linearity: Regulatory ...

    2013-3-19 · The diagnosis of cellulitis was made on clinical grounds by an attending physician. Investigation for DVT was performed by calculation of a pre-test probability using the Wells score, with a score of ≥2 designated high risk, and D-Dimer assay (IL D-Dimer HS, Instrumentation Laboratory, Italy) using 250 ng/ml as the positive cut-off .

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  • Prevalence of concurrent deep vein thrombosis in

    Multiple pitfalls can occur with the conduct and analysis of a study of diagnostic tests, resulting in biased accuracy. Our conceptual model includes three stages: patient selection, interpretation of the index test and disease verification. In part 2, we focus on (1) Interpretation bias (or workup bias): where the classification of an indeterminate index test result can bias the accuracy of a ...

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  • A Novel and Rapid Whole-Blood Assay for D-Dimer in ...

    1995-4-15 · The use of the D-dimer test in combination with non-invasive testing versus serial non-invasive testing alone for the diagnosis of deep-vein thrombosis. Thromb Haemost. 1992; 67:510-513. Crossref Medline Google Scholar; 19 Brenner B, Pery M, Lanir N, et al. Application of SimpliRED D-dimer in the diagnosis of deep vein thrombosis.

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  • Stago - Detail - STA®-Liatest® D-Di Plus, Less ...

    Select the best D-Dimer test for cost-effectiveness and safety. STA® -Liatest® D-Di has been clinically validated in outcome studies of over 4,000 patients with suspected DVT and PE to be used to safely aid in the diagnosis of VTE. Using the 0.5 μg/mL (FEU) threshold in conjunction with a pre-test probability assessment, the STA® -Liatest ...

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  • D-dimer as a biomarker for disease severity and

    2020-7-10 · The distributions of D-dimer levels among patients with different clinical staging, chest CT staging, and who survived and deceased during hospitalization are presented in Figs. 1, 2, 3, and 4.On admission, D-dimer levels significantly increased with increasing severity of COVID-19 as determined by clinical staging (Kendall’s tau-b = 0.374, P = 0.000), chest CT staging (Kendall’s tau-b = 0 ...

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  • IN BRIEF A Summary of the Evidence - CADTH.ca

    For example, a negative D-dimer test in a low-risk patient (determined by applying a CPR) may rule out PE; while a positive D-dimer test may mean a patient goes on to have diagnostic imaging. However, if a patient is at high risk for PE, based on their CPR assessment, they may go directly to have

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  • A cohort study of 676 patients indicates D-dimer is a ...

    2020-11-9 · D-dimer has the highest C-index to predict in-hospital mortality, and patients with D-dimer levels ≥0.5 mg/L had a higher incidence of mortality (Hazard Ratio: 4.39, P<0.01). Our study suggested D-dimer could be a potent marker to predict the mortality of COVID-19, which may be helpful for the management of patients.

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  • Moving beyond sensitivity and specificity: using ...

    2003-10-1 · What does a negative d-dimer test mean, in terms of the chance of having a deep vein thrombosis, for a 40-year-old female with a swollen calf? It is impossible for the clinician to know whether the positive result is a true positive or a false positive; or …

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  • Deep Venous Thrombosis (DVT) - Cardiovascular

    Here is a scatter plot of the data. Each of the individual measurements for each sample are plotted. The x-axis is the expected concentration of D-dimer for each sample, and the y-axis is. the measured concentration. A linear regression line with a slope of 0.992 and intercept of - 0.001 was fit to the points.

    Get Price
  • Calibration Verification and Linearity: Regulatory ...

    D-dimer is an end product of the degradation of fibrin clots. A positive result suggests DVT or PE, but the test has poor specificity (about 50%). Sensitivity is up to 98% but is lower in populations at high risk for VTE. A D-dimer level < 500 ng/mL by ELISA in conjunction with a …

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  • Deep Venous Thrombosis | Nutrition Guide for Clinicians

    2013-5-3 · Objective To review the diagnostic accuracy of D-dimer testing in older patients (>50 years) with suspected venous thromboembolism, using conventional or age adjusted D-dimer cut-off values. Design Systematic review and bivariate random effects meta-analysis. Data sources We searched Medline and Embase for studies published before 21 June 2012 and we contacted the authors of …

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